Yes, semaglutide may cause insomnia in some individuals, but it is considered a less common side effect.
Semaglutide is a GLP-1 receptor agonist used in medications like Ozempic and Wegovy to treat type 2 diabetes and support weight loss. While it’s generally well tolerated, some users have reported difficulty sleeping, especially in the early weeks of treatment.
Why might semaglutide cause insomnia?
Although insomnia is not listed as a primary or frequent side effect in clinical trials, a few mechanisms may explain sleep disturbances:
- Gastrointestinal Discomfort
Nausea, bloating, or acid reflux — common side effects of semaglutide — may interfere with sleep, especially if the medication is taken late in the day. - Changes in Blood Sugar
Blood sugar fluctuations can sometimes trigger restlessness or night awakenings. - Increased Alertness or Energy
As the body adapts to weight loss or metabolic improvements, some individuals may feel unusually energized, making it harder to fall asleep. - Dosing Time
Taking semaglutide close to bedtime may contribute to side effects that disrupt sleep.
What can you do if semaglutide causes insomnia?
If you’re experiencing insomnia after starting semaglutide, try the following:
- Adjust the timing: Take your dose earlier in the day to reduce the chance of nighttime discomfort.
- Eat light dinners: Avoid heavy or spicy meals that may worsen GI symptoms.
- Practice good sleep hygiene: Limit screen time, caffeine, and stress before bed.
- Track your sleep patterns: Keeping a sleep journal can help your provider assess the problem.
- Consult your provider: If insomnia persists beyond the adjustment period, your doctor may modify your dose or suggest alternatives.
When should you talk to your doctor?
If your sleep issues are frequent, worsening, or affecting your daily functioning, speak with your healthcare provider. Insomnia can lead to fatigue, mood changes, and other health problems if left unmanaged.
Insomnia is not a guaranteed side effect of semaglutide, but it can happen. Personalized medical advice is key — never adjust your dosage or stop medication without professional guidance.